Abstract
The introduction of fluorine in pharmaceuticals and agrochemicals can be highly advantageous. The substitution of one or just a few hydrogen atoms by fluorine can dramatically alter a compounds acidity/basicity and lipophilicity, which may result in an improvement of its biological and/or pharmaceutical properties. This chapter discusses issues associated with both fluorinated compounds and with the fluorination process, before looking at developments that have allowed reactions to be performed with less harsh reagents.
Publisher
The Royal Society of Chemistry