Lab-on-a-chip: Efficient Preparation of Bioactive Compounds Using On-chip Flow Synthesis

Author:

Chipoline Ingrid Cavalcanti12,Borges Pedro Henrique Oliveira12,Ferreira Sabrina Baptista1,Paes Silva Junior Floriano3

Affiliation:

1. a LaSOPB, Chemical Organic Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

2. b LABECFAR, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil

3. b LABECFAR, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil floriano@ioc.fiocruz.br

Abstract

Lab-on-a-chip (LOC) technology enables the efficient preparation of bioactive compounds through on-chip flow synthesis in microdevices. In this chapter, we provide an overview of device miniaturization, its benefits and challenges. We highlight the potential of LOC technology in both chemical synthesis and biological analysis, explore the principles of flow synthesis, present examples of LOC devices, and highlight the importance of the efficient preparation of such compounds. Additionally, we examine potential applications and prospects. This chapter underscores the promising role of LOC technology in advancing chemical synthesis and biological research.

Publisher

Royal Society of Chemistry

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