Affiliation:
1. Department of Chemistry, Materials and Chemical Engineering, “Giulio Natta”, Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy
Abstract
The speed of the various physiological processes that affect wound healing depends on therapeutic agents, such as cytokines, antibacterial agents, growth factors, small molecules, proteins and bioactive agents. In addition to the speed of healing, there are several factors that should be considered in deciding the route of administration of therapies. Localized controlled release in wound healing can provide spatiotemporal control over drug dosage at the wound site, protect drugs from metabolic deactivation and maintain constant drug concentrations for an extended period of time. To define a delivery system as optimal it should be able to sequentially and selectively release antibacterial agents, growth factors, cytokines and other small molecules in a controlled manner so that the wound follows a natural course of healing.
Publisher
Royal Society of Chemistry