Elevated serum antibody responses to synthetic mycobacterial lipid antigens among UK farmers: an indication of exposure to environmental mycobacteria?

Author:

Jones Alison1234,Davies Carys A.5234,Fitch Samuel5234,Al Dulayymi Juma'a R.1234,Gwenin Christopher D.12346,Gibbons James1234,Williams A. Prysor1234,Baird Mark S.5234ORCID

Affiliation:

1. School of Natural Sciences

2. Bangor University

3. Bangor

4. UK

5. School of Chemistry

6. Department of Chemistry

Abstract

Antibody binding to trehalose mycolates, such as that shown, was evaluated in ELISA. Median responses with the serum of individuals with no known mycobacterial infection were low; some were very high, the majority from Welsh farmers older than 55.

Funder

Llywodraeth Cymru

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Reference52 articles.

1. M. Daffé , A.Quémard and H.Marrakchi , Biogenesis of Fatty Acids, Lipids and Membranes , 2017 , pp. 1–36

2. Mycolic acids: structure, biosynthesis and physiological functions

3. Separation and characterization of individual mycolic acids in representative mycobacteria

4. Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acids

5. D. E. Minnikin , in The Biology of the Mycobacteria , ed. C. Ratledge and J. Stanford , Academic Press , London , 1982 , pp. 95–184

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