A phosphonium-based deep eutectic solvent promotes the stereoselective semi-reduction of internal alkynes to (<i>Z</i>)-alkenes-Reference-Cited by-同舟云学术

A phosphonium-based deep eutectic solvent promotes the stereoselective semi-reduction of internal alkynes to (Z)-alkenes

Published:2023 Issue:18 Volume:21 Page:3770-3777
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Paparella Andrea Nicola¹^ORCID,Messa Francesco¹^ORCID,Perrone Serena¹^ORCID,Salomone Antonio²^ORCID

Affiliation:

1. Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Prov.le Lecce-Monteroni, I-73100 Lecce, Italy

2. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy

Abstract

A chemo- and stereoselective Pd-catalysed semi-reduction of alkynes to (Z)-alkenes has been performed in a phosphonium-based DES by using the in situ generation of H2 from Al/H2O. The antitumor agent combretastatin A4 has been also synthesized.

Funder

Regione Puglia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00433C

Reference58 articles.

1. The ionic liquid microphase enhances the catalytic activity of Pd nanoparticles supported by a metal–organic framework

2. Aminopolymer–Silica Composite-Supported Pd Catalysts for Selective Hydrogenation of Alkynes

3. Palladium nanoparticles supported on mpg-C3N4 as active catalyst for semihydrogenation of phenylacetylene under mild conditions

4. Alkyne Semihydrogenation with a Well-Defined Nonclassical Co–H2 Catalyst: A H2 Spin on Isomerization and E-Selectivity

5. Highly efficient and recyclable ruthenium nanoparticle catalyst for semihydrogenation of alkynes

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