Binding mode prediction and identification of new lead compounds from natural products as renin and angiotensin converting enzyme inhibitors-Reference-Cited by-同舟云学术

Binding mode prediction and identification of new lead compounds from natural products as renin and angiotensin converting enzyme inhibitors

Published:2014 Issue:38 Volume:4 Page:19550-19568
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Moorthy N. S. Hari Narayana¹²³⁴⁵,Brás Natércia F.¹²³⁴⁵,Ramos Maria J.¹²³⁴⁵,Fernandes Pedro A.¹²³⁴⁵

Affiliation:

1. REQUIMTE

2. Departamento de Química e Bioquímica

3. Faculdade de Ciências

4. Universidade do Porto

5. Porto, Portugal

Abstract

In this study a novel renin and ACE inhibitor was developed from natural products using computational techniques. Molecular dynamic simulations showed that the new lead compound has significant binding to the targets.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA00856A

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