Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: <i>in vitro</i> studies-Reference-Cited by-同舟云学术

Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies

Published:2024 Issue:30 Volume:14 Page:21859-21873
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yasser Norhan¹²,Sroor Farid M.³^ORCID,El-Shorbagy Haidan M.¹²,Eissa Shaymaa M.¹,Hassaneen Hamdi M.⁴,Abdelhamid Ismail A.⁴^ORCID

Affiliation:

1. Department of Zoology, Faculty of Science, Cairo University, 12613 Giza, Egypt

2. Faculty of Biotechnology, October University for Modern Science and Arts, 6th October, Giza, Egypt

3. Organometallic and Organometalloid Chemistry Department, National Research Centre, 12622 Cairo, Egypt

4. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Abstract

A new series of pyrazole-based chalcones were synthesized and tested against MCF7, PC3, PACA2 and BJ1 as in vitro study. Gene expression, DNA damage, DNA fragmentation and molecular docking for were discussed.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03375B

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5. Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

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