Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative-Reference-Cited by-同舟云学术

Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative

Published:2017 Issue:19 Volume:19 Page:4509-4514
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Liu Min¹²³⁴,Zhang Chunxia¹²³⁴,Ding Mingruo¹²³⁴,Tang Bencan⁵⁶⁷⁸⁴^ORCID,Zhang Fengzhi¹²³⁴^ORCID

Affiliation:

1. College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region

2. Zhejiang University of Technology

3. Hangzhou

4. P. R. China

5. Department of Chemical and Environment Engineering

6. Science and Engineering Building

7. The University of Nottingham Ningbo China

8. Ningbo

Abstract

A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivatives with readily available aniline derivatives as starting materials.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/GC/C7GC01783A

Reference50 articles.

1. 3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities

2. Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

3. Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

4. Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents

5. Convolutamydine A, a novel bioactive hydroxyoxindole alkaloid from marine bryozoan Amathia convoluta

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