Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity-Reference-Cited by-同舟云学术

Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity

Published:2019 Issue:31 Volume:10 Page:7358-7364
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Freund Robert R. A.¹²³⁴^ORCID,Gobrecht Philipp⁵⁶⁷⁴,Rao Zhigang⁸²³⁴,Gerstmeier Jana⁸²³⁴,Schlosser Robin¹²³⁴,Görls Helmar⁹²³⁴,Werz Oliver⁸²³⁴,Fischer Dietmar⁵⁶⁷⁴^ORCID,Arndt Hans-Dieter¹²³⁴^ORCID

Affiliation:

1. Institut für Organische Chemie und Makromolekulare Chemie

2. Friedrich-Schiller-Universität

3. 07743 Jena

4. Germany

5. Lehrstuhl für Zellphysiologie

6. Ruhr-Universität Bochum

7. 44780 Bochum

8. Institut für Pharmazie

9. Institut für Anorganische Chemie und Analytische Chemie

Abstract

The discovery of novel allylboration reagents enabled to the stereoselective synthesis of parthenolides. Biological screening for microtubule detyrosination and nerve growth promotion revealed protein target selectivity.

Funder

Deutsche Forschungsgemeinschaft

Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC01473J

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