Curcumin–polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage-Reference-Cited by-同舟云学术

Curcumin–polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage

Published:2024 Issue:21 Volume:14 Page:14934-14941
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lei Li¹²^ORCID,Yuan Jiali¹,Yang Qingqing³,Tu Qiuxia¹,Yu Haijun⁴^ORCID,Chu Liangzhao²,Tang Lei³,Zhang Chunlin¹

Affiliation:

1. Engineering Research Center for Molecular Medicine, School of Basic Medical Science, Guizhou Medical University, Guiyang 550025, China

2. Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

3. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, College of Pharmacy, Guizhou Medical University, Guiyang, 550025, China

4. Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Abstract

A Cur–PDA NP based nanoregulator was developed for targeting ferroptosis to mitigate neuron degeneration by regulating iron and ROS homeostasis, suppressing lipid peroxidation and oxidative stress, and improving mitochondrial function.

Funder

National Natural Science Foundation of China

Guizhou Medical University

National College Students Innovation and Entrepreneurship Training Program

Guizhou Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02336F

Reference57 articles.

1. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

2. Regulation of Ferroptotic Cancer Cell Death by GPX4

3. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

4. Fenton's reagent revisited

5. Mechanisms of ferroptosis