Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release-Reference-Cited by-同舟云学术

Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release

Published:2021 Issue:7 Volume:12 Page:2389-2396
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zitterbart Robert¹²³^ORCID,Berger Nadja¹²³^ORCID,Reimann Oliver¹²³^ORCID,Noble Gavin T.⁴⁵⁶^ORCID,Lüdtke Stephan¹²³,Sarma Dominik¹²³,Seitz Oliver⁷²³^ORCID

Affiliation:

1. Belyntic GmbH

2. 12489 Berlin

3. Germany

4. Bachem (UK) Ltd.

5. Merseyside WA9 5GL

6. UK

7. Humboldt-Universität zu Berlin

Abstract

A first-in-class reductively cleavable linker system that enables parallel and traceless purification of peptides through a safety-release is introduced with three linker types and showcased by rapid production of 20 personalized neoantigen peptides.

Funder

Bundesministerium für Wirtschaft und Energie

European Social Fund

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06285E

Reference52 articles.

1. A Comprehensive Review on Current Advances in Peptide Drug Development and Design