Maternal inulin alleviates high-fat diet-induced lipid disorder in offspring by epigenetically modulating hypothalamus feeding circuit-related genes-Reference-Cited by-同舟云学术

Maternal inulin alleviates high-fat diet-induced lipid disorder in offspring by epigenetically modulating hypothalamus feeding circuit-related genes

Published:2024 Issue:1 Volume:15 Page:110-124
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Qian¹^ORCID,Xiao Xinhua¹^ORCID,Zheng Jia¹,Li Ming¹,Yu Miao¹,Ping Fan¹,Wang Tong¹

Affiliation:

1. Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China

Abstract

Maternal inulin intervention activates hypothalamic Socs3, Npy, and Il6 gene methylation, inhibits Lepr gene methylation, and moderates the hypothalamus feeding circuit, leading to a decrease in food intake and body weight in male offspring.

Funder

National Natural Science Foundation of China

Beijing Municipal Science and Technology Commission

National Basic Research Program of China

Natural Science Foundation of Beijing Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO02223D

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