Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats-Reference-Cited by-同舟云学术

Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats

Published:2023 Issue:20 Volume:14 Page:9265-9278
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ahmed Hanan H.¹^ORCID,Essam Reham M.²³^ORCID,El-Yamany Muhammed F.²,Ahmed Kawkab A.⁴^ORCID,El-Sahar Ayman E.²³^ORCID

Affiliation:

1. Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo, University, Cairo, Egypt

3. Biology Department, School of Pharmacy, Newgiza University, Giza, Egypt

4. Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

Abstract

The effects of CRS on inducing depression and the beneficial effect of LF in halting depression through mitigating ROS and pro-inflammatory cytokines, restoring corticosterone, 5-HT and BDNF levels, and modulating the hippocampal PI3K/Akt/mTOR/GSK-3β pathway were studied.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO02222F

Reference83 articles.

1. Anhedonia in Depression: Neurobiological and Genetic Aspects

2. Depression WHO , Other common mental disorders: global health estimates , World Health Organization , Geneva , 2017 , p. 24

3. PI3K/AKT/GSK3β/CRMP-2-mediated neuroplasticity in depression induced by stress

4. Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability

5. Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Electroconvulsive therapy combined with esketamine improved depression through PI3K/AKT/GLT-1 pathway;Journal of Affective Disorders;2024-09

2. PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression;Pharmacological Research;2024-08

3. Colostrum supplementation enhance mental health status and alleviate pain in patients with acetabular fracture: A randomized, controlled, clinical trial;Journal of Functional Foods;2024-08

4. The effects of baicalin in depression: preclinical evidence construction based on meta-analysis;Frontiers in Pharmacology;2024-07-24

5. Unlocking the power of Lactoferrin: Exploring its role in early life and its preventive potential for adult chronic diseases;Food Research International;2024-04