Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip-Reference-Cited by-同舟云学术

Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip

Published:2022 Issue:9 Volume:22 Page:1815-1828
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Paggi Carlo Alberto¹²,Hendriks Jan¹,Karperien Marcel¹^ORCID,Le Gac Séverine²^ORCID

Affiliation:

1. Department of Developmental BioEngineering, TechMed Centre, and Organ-on-chip Centre, University of Twente, Enschede, The Netherlands

2. Applied Microfluidics for BioEngineering Research, MESA+ Institute for Nanotechnology & TechMed Centre, and Organ-on-chip Centre, University of Twente, Enschede, The Netherlands

Abstract

The multi-directional mechanical stimulation experienced by cartilage during motion is transferred to chondrocytes, which respond by releasing matrix proteins and/or matrix-degrading enzymes.

Funder

ReumaNederland

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D1LC01069G

Reference62 articles.

1. Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

2. Osteoarthritis

3. Diagnosis and Management of Rheumatoid Arthritis

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review;Bioactive Materials;2025-01

2. Advances in skeletal genomics research across tissues and cells;Current Opinion in Genetics & Development;2024-10

3. The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis;Frontiers in Immunology;2024-09-11

4. An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel;Advanced Therapeutics;2024-08-02

5. The development, use, and challenges of electromechanical tissue stimulation systems;Artificial Organs;2024-06-18