Tetra-fluorinated aromatic azide for highly efficient bioconjugation in living cells

Author:

Cai Xuekang12345,Wang Dan678910,Gao Yasi511124,Yi Long51112413ORCID,Yang Xing123414ORCID,Xi Zhen678910

Affiliation:

1. Department of Nuclear Medicine

2. Peking University First Hospital

3. Beijing

4. China

5. State Key Laboratory of Organic–Inorganic Composites

6. State Key Laboratory of Elemento-Organic Chemistry

7. Department of Chemical Biology

8. National Pesticide Engineering Research Center (Tianjin)

9. Nankai University

10. Tianjin

11. Beijing University of Chemical Technology

12. Beijing 100029

13. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

14. Peking University School of Medical Technology

Abstract

A fast strain-promoted azide–alkyne cycloaddition based on tetra-fluorinated aromatic azide was developed and applied to label proteins and living cells with high efficiency.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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