Exploring the antimicrobial potential of isoniazid loaded Cu-based metal–organic frameworks as a novel strategy for effective killing of Mycobacterium tuberculosis

Author:

Kumar Pawan1,Behera Ananyaashree2,Tiwari Pranav1,Karthik Sibi3,Biswas Mainak2,Sonawane Avinash23,Mobin Shaikh M.1345ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology, Indore, Simrol, Madhya Pradesh, India

2. School of Biotechnology, KIIT Deemed to be University, Bhubaneswar, Odisha, India

3. Department of Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore, Simrol, Madhya Pradesh, India

4. Center for Advance Electronic (CAE), Indian Institute of Technology, Indore, Simrol, Madhya Pradesh, India

5. Center for Electric Vehicle and Intelligent Transport Systems, Indian Institute of Technology, Indore, Simrol, Madhya Pradesh, India

Abstract

Synthesis of IITI-3, INH encapsulation within IITI-3, their drug release, anti-mycobacterial activity and the mycobacterial biofilm inhibition phenomenon of INH@IITI-3.

Funder

Board of Research in Nuclear Sciences

Indian Institute of Technology Indore

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference104 articles.

1. Global tuberculosis report 2021, https://www.who.int/publications-detail-redirect/9789240037021 , (accessed August 28, 2022)

2. Tuberculosis Treatment and Drug Regimens

3. The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy

4. Host-directed therapies for bacterial and viral infections|Nature Reviews Drug Discovery, https://www.nature.com/articles/nrd.2017.162 , (accessed April 24, 2023)

5. M.Badrinath and S.John , StatPearls , StatPearls Publishing , Treasure Island (FL) , 2023

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