Enzymatically synthesized poly(amino-co-ester) polyplexes for systemic delivery of pcDNA-miRNA-214 to suppress colorectal cancer liver metastasis

Author:

Luo Hui-yan12345,Yang Zhe678910ORCID,Wei Wei112345,Li Ying-qin678910,Pu Hengying12345,Chen Ya12345,Sheng Hui12345,Liu Jie678910ORCID,Xu Rui-hua12345

Affiliation:

1. Department of Medical Oncology

2. Sun Yat-sen University Cancer Center

3. State Key Laboratory of Oncology in South China

4. Collaborative Innovation Center for Cancer Medicine

5. Guangzhou 510060

6. Department of Biomedical Engineering

7. School of Engineering

8. Sun Yat-sen University

9. Guangzhou

10. China

11. Department of Hepatobiliary Oncology

Abstract

Upregulation of miRNA-214 expression level by PPMS polyplexes can efficiently inhibit colorectal cancer liver metastasis.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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