Solvent-specific, DAST-mediated intramolecular Friedel–Crafts reaction: access to dibenzoxepine-fused spirooxindoles-Reference-Cited by-同舟云学术

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Solvent-specific, DAST-mediated intramolecular Friedel–Crafts reaction: access to dibenzoxepine-fused spirooxindoles

Published:2021 Issue:8 Volume:19 Page:1760-1768
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Samikannu Ramesh¹²³⁴⁵,Sethuraman Sankaranarayanan¹²³⁴⁵^ORCID,Akula Nagaraja¹²³⁴⁵,Radhakrishnan Vignesh¹²³⁴⁵^ORCID,Kamisetti Srinivasarao¹²³⁴⁵,Banu Shabana¹²³⁴⁵,Vetrichelvan Muthalagu¹²³⁴⁵^ORCID,Gupta Anuradha¹²³⁴⁵,Li Jianqing⁶⁷⁸⁹,Rampulla Richard⁶⁷¹⁰⁹,Mathur Arvind¹²³⁴⁵

Affiliation:

1. Department of Discovery Synthesis

2. Biocon Bristol Myers Squibb R&D Centre

3. Syngene International Ltd.

4. Bangalore 560100

5. India

6. Small Molecule Drug Discovery

7. Bristol Myers Squibb Research and Early Development

8. Cambridge

9. USA

10. Princeton

Abstract

DAST-mediated intramolecular Friedel–Crafts cyclization is developed for the synthesis of novel spirooxindoles fused with dibenzoxepine moieties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02461A

Reference53 articles.

1. An overview of spirooxindole as a promising scaffold for novel drug discovery

2. The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents

3. Therapeutic Potential of Spirooxindoles as Antiviral Agents

4. Spirooxindoles as Potential Pharmacophores

5. Molecular diversity of spirooxindoles. Synthesis and biological activity

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1. Isolation and Reactions of Imidoyl Fluorides Generated from Oxime Using the Diethylaminosulfur Trifluoride/Tetrahydrofuran (DAST–THF) System;Organic Letters;2023-05-09

2. Seven-membered rings;Progress in Heterocyclic Chemistry;2023

3. Diethylaminosulfur Trifluoride (DAST) Mediated Transformations Leading to Valuable Building Blocks and Bioactive Compounds;European Journal of Organic Chemistry;2021-09-30

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