Unique assembly of carbonylpyridinium and chromene reveals mitochondrial thiol starvation under ferroptosis and novel ferroptosis inducer-Reference-Cited by-同舟云学术

Unique assembly of carbonylpyridinium and chromene reveals mitochondrial thiol starvation under ferroptosis and novel ferroptosis inducer

Published:2022 Issue:13 Volume:13 Page:3706-3712
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ma Kaiqing¹^ORCID,Yang He¹,Shen Tianruo²,Yue Yongkang¹,Zhao Lingling¹,Liu Xiaogang²^ORCID,Huo Fangjun³^ORCID,Yin Caixia¹^ORCID

Affiliation:

1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, PR China

2. University of Technology and Design, 487372, Singapore

3. Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, PR China

Abstract

Carbonylpyridinium and chromene were elaborately assembled to highly target mitochondrial thiol assay by releasing o-quinone methide from CM-Mit to label proteins, thus avoiding diffusion out of the mitochondria, which enabled accurately spatiotemporal detection of thiol.

Funder

National Natural Science Foundation of China

Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes

Scientific Instrument Center, SXU

Fund for Shanxi Key Subjects Construction

Shanxi Provincial Key Research and Development Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00328G