A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles-Reference-Cited by-同舟云学术

A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles

Published:2022 Issue:2 Volume:3 Page:242-249
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Santana-Mederos Darielys¹^ORCID,Perez-Nicado Rocmira¹^ORCID,Climent Yanet¹^ORCID,Rodriguez Laura¹^ORCID,Ramirez Belinda Sanchez²,Perez-Rodriguez Sonia³,Rodriguez Meybi¹,Labrada Claudia¹^ORCID,Hernandez Tays²,Diaz Marianniz²^ORCID,Orosa Ivette²^ORCID,Ramirez Ubel¹,Oliva Reynaldo¹^ORCID,Garrido Raine¹^ORCID,Cardoso Felix¹,Landys Mario¹,Martinez Roselyn¹,Gonzalez Humberto¹,Hernandez Tamara¹,Ochoa-Azze Rolando¹,Perez Jose L.¹,Enriquez Juliet⁴,Gonzalez Nibaldo⁴,Infante Yenicet⁴,Espinosa Luis A.⁵^ORCID,Ramos Yassel⁵,González Luis Javier⁵,Valenzuela Carmen⁶,Casadesus Ana Victoria²,Fernandez Briandy²^ORCID,Rojas Gertrudis²^ORCID,Pérez-Massón Beatriz²^ORCID,Tundidor Yaima²^ORCID,Bermudez Ernesto²,Plasencia Claudia A.²,Boggiano Tammy²^ORCID,Ojito Eduardo²^ORCID,Chiodo Fabrizio¹⁷^ORCID,Fernandez Sonsire¹^ORCID,Paquet Françoise⁸^ORCID,Fang Cheng⁹,Chen Guang-Wu¹⁰,Rivera Daniel G.¹¹^ORCID,Valdes-Balbin Yury¹,Garcia-Rivera Dagmar¹^ORCID,Verez Bencomo Vicente¹^ORCID

Affiliation:

1. Finlay Vaccine Institute, 200 and 21 Street, Havana 11600, Cuba

2. Center of Molecular Immunology, P.O. Box 16040, 216 St., Havana, Cuba

3. National Toxicology Center, Havana, 11500, Cuba

4. National Civil Defense Research Laboratory, Mayabeque 32700, Cuba

5. Center for Genetic Engineering and Biotechnology, Ave 31 e/158 y 190, Havana 10600, Cuba

6. Institute of Cybernetics, Mathematics and Physics, Havana 10400, Cuba

7. Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands and Institute of Biomolecular Chemistry, National Research Council (CNR), Pozzuoli, Napoli, Italy

8. Centre de Biophysique Moléculaire, CNRS UPR 4301, rue Charles Sadron, F-45071, Orléans Cedex 2, France

9. Shanghai Fenglin Glycodrug Promotion Center, Shanghai 200032, China

10. Chengdu Olisynn Biotech. Co. Ltd., and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China

11. Laboratory of Synthetic and Biomolecular Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Havana 10400, Cuba

Abstract

Soberana01 is composed of the SARS-CoV-2 dimeric RBD and Neisseria meningitidis outer membrane vesicles (OMVs) adsorbed on alum. This vaccine induces a potent neutralizing immune response and shows potential against SARS-CoV-2 variants of concern.

Funder

Deutscher Akademischer Austauschdienst

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D1CB00200G

Reference40 articles.

1. SARS-CoV-2 vaccines in development

2. A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

3. COVID-19 vaccines: rapid development, implications, challenges and future prospects