Organocatalytic diastereoselective [3+2] cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2

Organocatalytic diastereoselective [3+2] cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2–p53 interaction

Published:2019 Issue:76 Volume:55 Page:11374-11377
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhu Hong-Ping¹²³⁴⁵,Xie Ke⁶⁷⁸⁵,He Xiang-Hong¹²³⁴⁵^ORCID,Huang Wei¹²³⁴⁵^ORCID,Zeng Rong⁶⁷⁸⁵,Fan Yang⁶⁷⁸⁵,Peng Cheng¹²³⁴⁵^ORCID,He Gu⁹¹⁰¹¹⁵^ORCID,Han Bo¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Southwestern Chinese Medicine Resources

2. School of Pharmacy

3. Chengdu University of Traditional Chinese Medicine

4. Chengdu

5. China

6. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics

7. Chengdu University

8. Chengdu 610052

9. State Key Laboratory of Biotherapy and Cancer Center

10. West China Hospital, Sichuan University

11. Chengdu 610041

Abstract

MBH carbonates were successfully applied to a stereoselective [3+3] annulation with N,C-dinucleophiles for the first time, yielding a collection of pharmacologically interesting bicyclic imidazolines which were found to inhibit MDM2–p53 binding.

Funder

Department of Science and Technology of Sichuan Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC05916D

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