Microvortex-induced turbulent mixing for reconstitution of high-density lipoprotein-mimicking nanoparticles with aggregation-prone phosphatidylcholine

Author:

Takata Koji12,Shibukawa Shiori1ORCID,Morimoto Chika3,Hashioka Shingi4,Murakami Tatsuya15ORCID

Affiliation:

1. Graduate School or Engineering, Toyama Prefectural University, Imizu, Toyama, 939-0398, Japan

2. Human Life Technology Research Institute, Toyama Industrial Technology Research and Development Center, Nanto, Toyama, 939-1503, Japan

3. R&D Center, Zeon Corporation, Kawasaki, Kanagawa, 210-9507, Japan

4. R&D Center, Zeon Corporation, Takaoka, Toyama, 933-8516, Japan

5. Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan

Abstract

Lipid nanoparticles often contain a phosphatidylcholine with a long chain fatty acid, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC).

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

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