Versatile fully-substituted triazole-functionalized polypeptides with a stable α-helical conformation for gene delivery-Reference-Cited by-同舟云学术

Versatile fully-substituted triazole-functionalized polypeptides with a stable α-helical conformation for gene delivery

Published:2022 Issue:35 Volume:13 Page:5042-5047
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Xu Xiang¹,Liu Shuxin¹,Gao He¹,Li Ming¹,He Junnan¹,Zheng Yubin¹,Song Wangze¹^ORCID,Zheng Nan¹^ORCID

Affiliation:

1. Department of Polymer Science and Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, P. R. China

Abstract

A library of polypeptides bearing fully-substituted triazoles (FT) was developed via a Cu-catalyzed multicomponent reaction (MCR), which avoided the undesired hydrogen bonding and stabilized the α-helix in a broad pH range.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/PY/D2PY00894G

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