Near infra-red luminescent osmium labelled gold nanoparticles for cellular imaging and singlet oxygen generation-Reference-Cited by-同舟云学术

Near infra-red luminescent osmium labelled gold nanoparticles for cellular imaging and singlet oxygen generation

Published:2024 Issue:35 Volume:16 Page:16500-16509
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Watson Luke S.¹,Hughes Joseph¹,Rafik Salma T.²³,Muguruza Asier R.¹^ORCID,Girio Patricia M.¹⁴,Akponasa Sarah O.¹⁵,Rochford Garret⁵,MacRobert Alexander J.²,Hodges Nikolas J.⁵,Yaghini Elnaz²,Pikramenou Zoe¹^ORCID

Affiliation:

1. School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK

2. Dept. of Surgical Biotechnology, Faculty of Medical Sciences, University College London, London, UK

3. Department of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria 21516, Egypt

4. Doctoral Training Centre in Physical Sciences for Health, University of Birmingham, Edgbaston, B15 2TT, UK

5. School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, UK

Abstract

Dual modality nanoprobes with enhanced theranostic properties are designed by decoration of gold nanoparticles with osmium complexes for imaging in the near-infrared and singlet oxygen production, leading to new localised therapy approaches.

Funder

University of Birmingham

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Ministry of Higher Education

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D4NR01901F

Reference73 articles.

1. Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications

2. Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics

3. Phosphorescent metal complexes as theranostic anticancer agents: combining imaging and therapy in a single molecule

4. Osmium(ii) polypyridyl polyarginine conjugate as a probe for live cell imaging; a comparison of uptake, localization and cytotoxicity with its ruthenium(ii) analogue

5. Mitochondrial targeted osmium polypyridyl probe shows concentration dependent uptake, localisation and mechanism of cell death