Boosted photo-immunotherapy via near-infrared light excited phototherapy in tumor sites and photo-activation in sentinel lymph nodes

Author:

Wang Chen1,Gu Bobo1ORCID,Qi Shuhong23,Hu Siyi4ORCID,Wang Yu5ORCID

Affiliation:

1. Med-X Research Institute & School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China

2. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China

3. MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China

4. CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China

5. Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China

Abstract

A new phototherapy strategy using ICG NPs is proposed to boost photo-immunotherapeutical outcomes. The phototherapy on the tumor site eradicated solid tumors while photo-activation on the sentinel lymph node triggered an efficient immune response.

Funder

National Natural Science Foundation of China

Shanghai Jiao Tong University

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

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