Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems

Author:

Zhoujin Yunping1,Li Yuping1,Zhang Mingtao2ORCID,Parkin Sean3ORCID,Guo Ju1,Li Tonglei4ORCID,Yu Faquan1ORCID,Long Sihui1ORCID

Affiliation:

1. Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 206 1st Rd Optics Valley, East Lake New Technology Development District, Wuhan, Hubei 430205, China

2. Computational Center for Molecular Science, College of Chemistry, Nankai University, Tianjin, China

3. Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA

4. Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USA

Abstract

Isomorphism and isostructurality were observed between form I of 2-((2,6-dimethylphenyl)amino)benzoic acid and its analog 2-((2,6-dichlorophenyl)amino)benzoic acid, which suggests double Cl–CH3 exchange also leads to structural similarity.

Funder

Natural Science Foundation of Hubei Province

Wuhan Institute of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

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3. Crystal structure of ethyl 2-((4-(3,5-dimethylisoxazol-4-yl)-2,6-difluorophenyl)amino)benzoate, C20H18F2N2O3;Zeitschrift für Kristallographie - New Crystal Structures;2023-11-08

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