Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining-Reference-Cited by-同舟云学术

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

Published:2023 Issue:1 Volume:40 Page:89-127
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Chiang Chen-Yu¹,Ohashi Masao¹^ORCID,Tang Yi¹²^ORCID

Affiliation:

1. Dept. of Chemical and Biomolecular Engineering, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA

2. Dept. of Chemistry and Biochemistry, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA

Abstract

Heterologous expression of biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of new natural product variants.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NP/D2NP00050D

Reference201 articles.

1. Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

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3. Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

4. Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase

5. Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria

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