Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma-Reference-Cited by-同舟云学术

Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma

Published:2017 Issue:29 Volume:5 Page:5816-5834
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Davoodi Pooya¹²³,Srinivasan Madapusi P.¹²³⁴⁵,Wang Chi-Hwa¹²³^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering

2. National University of Singapore

3. Singapore

4. Civil

5. Environmental and Chemical Engineering

Abstract

Using core–shell microparticles encapsulating p53/β-CD-g-CS NPs and nutlin-3a effectively suppressed p53–MDM2 interaction and restored p53 apoptotic activity in cancer cells.

Funder

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TB/C7TB00481H

Reference56 articles.

1. From tumor prevention to therapy: Empowering p53 to fight back

2. Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities

3. Drosophila p53 Binds a Damage Response Element at the reaper Locus