Roles of different amino-acid residues towards binding and selective transport of K+ through KcsA K+-ion channel

Author:

De Susmita12345ORCID,C. H. Rinsha678910,Thamleena A. Hanna678910,Joseph Annu678910,Ben Anju678910,V. U. Krishnapriya678910

Affiliation:

1. Department of Applied Chemistry

2. Cochin University of Science and Technology

3. Trikakkara

4. Kochi

5. India – 682 022

6. Theoretical and Computational Chemistry Laboratory

7. Department of Chemistry

8. National Institute of Technology Calicut

9. Kozhikode

10. India – 673 601

Abstract

Each amino acid in the selectivity filter plays a distinct role towards binding and transport of K+ ion through KcsA.

Funder

Department of Science and Technology, Ministry of Science and Technology

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference111 articles.

1. B. Hille , Ion Channels of Excitable Membranes , Sinauer Associates, Inc. , 3rd edn, 2001

2. B. Alberts , A.Johnson , J.Lewis , M.Raff , K.Roberts and P.Walter , Molecular Biology of the Cell , Garland Science , New York , 4th edn, 2002 , ch. 10 and 11

3. Synthetic Ion Channel Activity Documented by Electrophysiological Methods in Living Cells

4. Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages: An Inorganic Mimic of K + Ion Channels

5. Computer simulations of membrane proteins

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