Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors-Reference-Cited by-同舟云学术

Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors

Published:2024 Issue:2 Volume:12 Page:448-465
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Arachchige Dilka Liyana¹²,Dwivedi Sushil K.¹²,Waters May¹²,Jaeger Sophia¹²,Peters Joe¹²,Tucker Daniel R.¹,Geborkoff Micaela³,Werner Thomas³,Luck Rudy L.¹^ORCID,Godugu Bhaskar⁴,Liu Haiying¹²^ORCID

Affiliation:

1. Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA

2. Health Research Institute, Michigan Technological University, Houghton, MI 49931, USA

3. Department of Biological Sciences, Michigan Technological University, Houghton, MI 49931, USA

4. Department of Chemistry, University of Pittsburgh, Chevron Science Center, 219 Parkman Avenue, Pittsburgh, PA 15260, USA

Abstract

Probes A and B were developed for NAD(P)H sensing, exhibiting responsive near-infrared emissions with minimal photodamage and effective tissue penetration. Probes C, D, and E showed reduced responsiveness to NAD(P)H.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02124F

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