Integrated metabolomics revealed the photothermal therapy of melanoma by Mo2C nanosheets: toward rehabilitated homeostasis in metabolome combined lipidome

Author:

Zhang Dingkun12ORCID,Wang Ming3,Li Yijin12,Liang Ge4,Zheng Wen4,Gui Luolan4,Li Xin4ORCID,Zhang Lu4,Zeng Wenjuan4ORCID,Yang Yin5,Zeng Yu4,Huang Zhe3,Fan Rong67,Lu Yang67ORCID,Guan Junwen8,Li Tao9,Cheng Jingqiu12,Yang Hao12ORCID,Chen Ligang3,Zhou Jie3,Gong Meng12

Affiliation:

1. Department of Plastic and Burn Surgery, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, P. R. China

2. NHC Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China

3. Department of Neurosurgery, Sichuan Clinical Medical Research Center for Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China

4. Metabolomics and Proteomics Technology Platform, West China Hospital, Sichuan University, Chengdu, P. R. China

5. Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu, 610041, China

6. Department of Mechanical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, P. R. China

7. Chengdu Research Institute, City University of Hong Kong, Chengdu, P. R. China

8. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China

9. Laboratory of Mitochondria and Metabolism, Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

In this work, Mo2C nanosheet-based photothermal therapy toward melanoma was investigated through integrated metabolomics in the mice model.

Funder

Science and Technology Department of Sichuan Province

National Natural Science Foundation of China

West China Hospital, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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