Wheat pathogenZymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
Author:
Affiliation:
1. Department of Chemistry
2. Imperial College London
3. Molecular Sciences Research Hub
4. London W12 0BZ
5. UK
6. The Francis Crick Institute
7. London NW1 1AT
8. Syngenta AG
9. Jealott's Hill Research Centre
10. Bracknell
Abstract
Investigation of the downstream effects of NMT inhibition identified novel defense mechanism against chemical toxicity in fungal pathogenZ. tritici.
Funder
Francis Crick Institute
FP7 People: Marie-Curie Actions
Wellcome Trust
Medical Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2020/CB/D0CB00020E
Reference56 articles.
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2. The wheat–Septoria conflict: a new front opening up?
3. Transcriptome and Metabolite Profiling of the Infection Cycle of Zymoseptoria tritici on Wheat Reveals a Biphasic Interaction with Plant Immunity Involving Differential Pathogen Chromosomal Contributions and a Variation on the Hemibiotrophic Lifestyle Definition
4. IPM Strategies and Their Dilemmas Including an Introduction to www.eurowheat.org
5. Fungicide Resistance Action Group, Fungicide resistance management in cereals , 2017
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