MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition-Reference-Cited by-同舟云学术

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

Published:2015 Issue:1 Volume:3 Page:41-45
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Chu D. S.¹²³⁴,Sellers D. L.⁵²³⁴,Bocek M. J.¹²³⁴,Fischedick A. E.⁵²³⁴,Horner P. J.⁵²³⁴,Pun S. H.¹²³⁴

Affiliation:

1. Department of Bioengineering and Molecular Engineering and Sciences Institute

2. University of Washington

3. Seattle

4. USA

5. Department of Neurological Surgery and Institute for Stem Cell and Regenerative Medicine

Abstract

Enzymatically-responsive bivalirudin polymers loaded in thermoresponsive hydrogels mediate localized therapeutic peptide delivery in spinal cord injuries. These materials respond to upregulated remodelling enzymes to release therapeutic peptide into injured tissue.

Funder

Craig H. Neilsen Foundation

National Institute of Neurological Disorders and Stroke

Congressionally Directed Medical Research Programs

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2015/BM/C4BM00259H

Reference22 articles.

1. K. A. Dunham and C. L.Floyd, in Animal Models of Movement Disorders: Volume II, ed. E. L. Lane and S. B. Dunnett, Humana Press, London, United Kingdom, 2011, vol. 62, pp. 345–362