In vitro antitumor activity of dialkylamine-1,4-naphthoquinones toward human glioblastoma multiforme cells

Author:

Clementino-Neto José12,da Silva João Kaycke Sarmento1,de Melo Bastos Cavalcante Cibelle12,da Silva-Júnior Paulo Fernando3,David Cibelle Cabral4,de Araújo Morgana Vital1,Mendes Carmelita Bastos2,de Queiroz Aline Cavalcanti15ORCID,da Silva Elaine Cristina Oliveira6,de Souza Samuel Teixeira6,da Silva Fonseca Eduardo Jorge6ORCID,da Silva Tânia Maria Sarmento4,de Amorim Camara Celso4ORCID,Moura-Neto Vivaldo7,de Araújo-Júnior João Xavier38,da Silva-Júnior Edeildo Ferreira3ORCID,da-Silva Adriana Ximenes2ORCID,Alexandre-Moreira Magna Suzana1ORCID

Affiliation:

1. Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, AL, Brazil

2. Laboratory of Electrophysiology and Brain Metabolism, Institute of Biological Sciences and Health, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, AL, Brazil

3. Chemistry and Biotechnology Institute, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, AL, Brazil

4. Laboratory of Bioactive Compounds Synthesis, Molecular Sciences Department, Federal Rural University of Pernambuco, Campus Dois Irmãos, Dom Manuel de Medeiros Street, Recife 57171-900, PE, Brazil

5. Laboratory of Microbiology, Immunology and Parasitology, Complex Of Medical Sciences And Nursing, Federal University of Alagoas, Campus Arapiraca, Manoel Severino Barbosa Avenue, Arapiraca 57309-005, AL, Brazil

6. Laboratory of Characterization and Microscopy of Materials, Institute of Physics, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió, 57072, AL, Brazil

7. State Institute of Brain Paulo Niemeyer, Rezende Street, Rio de Janeiro 20231-092, RJ, Brazil

8. Laboratory of Medicinal Chemistry, Pharmaceutical Sciences Institute, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, AL, Brazil

Abstract

In this study, we evaluated the in vitro antitumor activity of dialkylamino-1,4-naphthoquinones (1a–n) toward human glioblastoma multiforme cells (GBM02).

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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