A highly GSH-sensitive SN-38 prodrug with an “OFF-to-ON” fluorescence switch as a bifunctional anticancer agent-Reference-Cited by-同舟云学术

A highly GSH-sensitive SN-38 prodrug with an “OFF-to-ON” fluorescence switch as a bifunctional anticancer agent

Published:2018 Issue:65 Volume:54 Page:9031-9034
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Whang Chang-Hee¹²³⁴^ORCID,Yoo Eunsoo⁵⁶⁷⁸⁴,Hur Seong Kwon⁹¹⁰⁸⁴,Kim Kyeong Soo¹²³⁴,Kim Dongin⁵⁶⁷⁸⁴,Jo Seongbong¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutics and Drug Delivery, School of Pharmacy

2. The University of Mississippi

3. University

4. USA

5. Department of Pharmaceutical Sciences

6. Irma Lerma Rangel College of Pharmacy

7. Texas A&M Health Science Center

8. College Station

9. Department of Molecular & Cellular Medicine

10. College of Medicine, Texas A&M Health Science Center

Abstract

A DNS-SN38 prodrug that is capable of GSH-sensitive activation of quenched fluorescence for bifunctional application.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC05010D

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