Tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling-Reference-Cited by-同舟云学术

Tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling

Published:2022 Issue:3 Volume:13 Page:763-774
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tang Kuei C.¹,Maddox Sean M.²³,Backus Keriann M.²³^ORCID,Raj Monika¹^ORCID

Affiliation:

1. Department of Chemistry, Emory University, Atlanta, GA 30322, USA

2. Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA

3. Department of Chemistry and Biochemistry, College of Arts and Sciences, UCLA, Los Angeles, CA, 90095, USA

Abstract

Here we report a new series of hydrolytically stable chemotype heteroaromatic azoline thioethers (HATs) to achieve highly selective, rapid, and efficient covalent labeling of cysteine under physiological conditions.

Funder

National Institutes of Health

Alfred P. Sloan Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC04139H

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