One-pot three-component coupling access to 1,2-dihydropyrrolo[1,2-a]pyrazine-1-phosphonates: multi-functionalization of a pyrazine unit-Reference-Cited by-同舟云学术

One-pot three-component coupling access to 1,2-dihydropyrrolo[1,2-a]pyrazine-1-phosphonates: multi-functionalization of a pyrazine unit

Published:2021 Issue:27 Volume:19 Page:6066-6084
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lee Jeong Hwa¹²³⁴,Yoon Seok Hyun⁵²³⁴^ORCID,Nam Seonghyeon¹²³⁴,Kim Ikyon¹²³⁴^ORCID

Affiliation:

1. College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences

2. Yonsei University

3. Incheon

4. Republic of Korea

5. Graduate Program of Industrial Pharmaceutical Sciences

Abstract

A highly efficient domino one-pot three-component Kabachnik–Fields coupling-intramolecular dehydrative cyclization process allowed facile access to 1,2-dihydropyrrolo[1,2-a]pyrazine-1-phosphonates with a densely-functionalized pyrazine unit.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00885D

Reference27 articles.

1. Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena

2. Novel Pyrrolo[1,2-a]Pyrazines (TSPO Ligands) with Anxiolytic Activity Dependent on Neurosteroid Biosynthesis

3. Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor

4. Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors

5. Synthesis and Antiproliferative Effect of Ethyl 4-[4-(4-Substituted Piperidin-1-yl)]benzylpyrrolo[1,2-a ]quinoxalinecarboxylate Derivatives on Human Leukemia Cells

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