Efficient synthesis of 1-azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β for cellular regeneration-Reference-Cited by-同舟云学术

Efficient synthesis of 1-azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β for cellular regeneration

Published:2024 Issue:27 Volume:48 Page:12081-12085
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Xu Yujiao¹²,Liu Jianguang²,Li Gengwu¹²,Wu Hua³,Du Xinghan³,Ma Tianhua³,Liu Dan¹,Tang Shibing¹²^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

2. State Key Laboratory of Respiratory Disease, Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, P. R. China

3. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China

Abstract

The selective GSK-3β inhibitor 1-azakenpaullone has broad applications in cellular regeneration and regenerative medicine. A two-step protocol featuring an indium-trichloride-mediated intramolecular cyclization to 1-azakenpaullone is disclosed.

Funder

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D4NJ00434E

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