<i>N</i>-2,2,2-Trifluoroethylisatin ketimine as a 1,2-dipolarophile for [3 + 2]-addition to access optically pure spirothiazolidine oxindoles-Reference-Cited by-同舟云学术

N-2,2,2-Trifluoroethylisatin ketimine as a 1,2-dipolarophile for [3 + 2]-addition to access optically pure spirothiazolidine oxindoles

Published:2023 Issue:24 Volume:21 Page:4972-4976
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Prasad Madavi S.¹^ORCID,Bharani Sankar¹,Sivaprakash Murugesan¹,Vadivelu Prabha¹,Kumar Durairajan Siva Sundara²,Chowhan L. Raju³^ORCID

Affiliation:

1. Asymmetric synthesis and catalysis laboratory, Department of Chemistry, Central University of Tamil Nadu (CUTN), Tiruvarur-610 005, India

2. Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu (CUTN), Tiruvarur-610 005, India

3. School of Physical Sciences, Jawaharlal Nehru University, New Delhi-110067, India

Abstract

The first asymmetric synthesis of N-2,2,2-trifluoroethylspirothiazolidine oxindoles is presented where N-2,2,2-trifluoroethylisatin ketimine is employed as a 1,2-dipolarophile for the first time in a [3 + 2]-addition reaction.

Funder

Biotechnology Industry Research Assistance Council

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00685A

Reference26 articles.

1. Discovery of 2-Arylthiazolidine-4-carboxylic Acid Amides as a New Class of Cytotoxic Agents for Prostate Cancer

2. Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2′-thiazolidine]-Based p53 Modulators

3. Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties

4. Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of theMycobacterium tuberculosisProtein Tyrosine Phosphatase B

5. Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B

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