<sup>19</sup>F chemical library and <sup>19</sup>F-NMR for a weakly bound complex structure-Reference-Cited by-同舟云学术

¹⁹F chemical library and ¹⁹F-NMR for a weakly bound complex structure

Published:2022 Issue:9 Volume:13 Page:1100-1111
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Shinya Shoko¹,Katahira Ritsuko¹,Furuita Kyoko¹,Sugiki Toshihiko¹,Lee Young-Ho¹²³⁴^ORCID,Hattori Yoshikazu¹,Takeshita Kohei¹,Nakagawa Atsushi¹^ORCID,Kokago Aoi⁵,Akagi Ken-ichi⁶,Oouchi Muneki⁷,Hayashi Fumiaki⁷,Kigawa Takanori⁸^ORCID,Takimoto-Kamimura Midori⁹,Fujiwara Toshimichi¹^ORCID,Kojima Chojiro¹⁵^ORCID

Affiliation:

1. Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan

2. Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Chungbuk 28119, South Korea

3. Bio-Analytical Science, University of Science and Technology, Daejeon 34113, South Korea

4. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, South Korea

5. Graduate School of Engineering Science, Yokohama National University, Tokiwadai 79-5, Hodogaya-ku, Yokohama 2408501, Japan

6. National Institute of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito Asagi, Ibaraki-city, Osaka 567-0085, Japan

7. RIKEN Spring-8 Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

8. RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

9. Quantum-Structural Life Science Laboratories, CBI Research Institute, 3-11-1 Shibaura, Minato-ku, Tokyo 108-0023, Japan

Abstract

19F-NMR analysis using the optimized 19F chemical library enables the modeling of the structure of the weakly bound protein–compound complex, overcoming the difficulty in fragment-based drug discovery.

Funder

Osaka University

Ministry of Education, Culture, Sports, Science and Technology

National Research Foundation of Korea

Korea Basic Science Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00170E

Reference28 articles.