Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection-Reference-Cited by-同舟云学术

Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection

Published:2019 Issue:6 Volume:17 Page:1384-1388
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Otake Yuma¹²³⁴⁵^ORCID,Williams Jason D.¹²³⁴⁵^ORCID,Rincón Juan A.⁶⁷⁸^ORCID,de Frutos Oscar⁶⁷⁸,Mateos Carlos⁶⁷⁸^ORCID,Kappe C. Oliver¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Chemistry

2. University of Graz

3. NAWI Graz

4. 8010 Graz

5. Austria

6. Centro de Investigación Lilly S.A.

7. 28108 Alcobendas-Madrid

8. Spain

Abstract

Photochemical benzylic bromination in flow using BrCCl₃, which is compatible with electron-rich aromatics, allowing in situ p-methoxybenzyl bromide formation and PMB-protection.

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00044E

Reference53 articles.

1. Brominations with N-Bromosuccinimide and Related Compounds. The Wohl-Ziegler Reaction.

2. Use of Bromine and Bromo-Organic Compounds in Organic Synthesis

3. N-bromosuccinimide. Mechanisms of allylic bromination and related reactions

4. Succinimidyl radical as a chain carrier. Mechanism of allylic bromination

5. Mechanisms of Benzylic Bromination

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