Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs

Author:

Ali Aliaa1,Bhadane Rajendra12ORCID,Asl Afshin Ansari13,Wilén Carl-Eric3,Salo-Ahen Outi12ORCID,Rosenholm Jessica M.1ORCID,Bansal Kuldeep K.13ORCID

Affiliation:

1. Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, BioCity (3rd floor), Tykistökatu 6A, 20520 Turku, Finland

2. Structural Bioinformatics Laboratory, Faculty of Science and Engineering, Biochemistry, Åbo Akademi University, 20520 Turku, Finland

3. Laboratory of Molecular Science and Engineering, Åbo Akademi University, Aurum, Henrikinkatu 2, 20500 Turku, Finland

Abstract

Block copolymer micelles with a functional core have been synthesized and evaluated for their drug delivery capability. High drug loading was observed due to strong ionic interactions, while cytotoxicity of polymers was found to be low.

Funder

Business Finland

Stiftelsen fõr Âbo Akademi

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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