Structure-guided evolution of carbonyl reductase for efficient biosynthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate-Reference-Cited by-同舟云学术

Structure-guided evolution of carbonyl reductase for efficient biosynthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate

Published:2020 Issue:22 Volume:10 Page:7512-7522
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Tang Wen¹²³⁴⁵,Chen Lulu¹²³⁴⁵,Deng Jian¹²³⁴⁵,Kuang Yuyao¹²³⁴⁵,Chen Chao¹⁶⁷³⁴,Yin Bo⁸⁹⁵,Wang Hualei¹²³⁴⁵^ORCID,Lin Jinping¹²³⁴⁵^ORCID,Wei Dongzhi¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering

2. New World Institute of Biotechnology

3. East China University of Science and Technology

4. Shanghai 200237

5. People's Republic of China

6. Biomedical Nanotechnology Center

7. School of Biotechnology

8. National University of Singapore (Suzhou) Research Institute

9. Suzhou 215123

Abstract

This study reported an attractive engineered carbonyl reductase from Gluconobacter oxydans through a structure-guided rational design to catalyze the synthesis of high concentration (R)-HPBE.

Funder

Natural Science Foundation of Shanghai

Fundamental Research Funds for the Central Universities

State Key Laboratory of Bioreactor Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CY/D0CY01411G

Reference46 articles.

1. Enzymatic synthesis of enantiopure alcohols: current state and perspectives