Comparative study of holothurin A and echinoside A on inhibiting the high bone turnover <i>via</i> downregulating PI3K/AKT/β-catenin and OPG/RANKL/NF-κB signaling in ovariectomized mice-Reference-Cited by-同舟云学术

Comparative study of holothurin A and echinoside A on inhibiting the high bone turnover via downregulating PI3K/AKT/β-catenin and OPG/RANKL/NF-κB signaling in ovariectomized mice

Published:2022 Issue:8 Volume:13 Page:4748-4756
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yue Hao¹^ORCID,Tian Yingying¹²,Li Yanqi¹,Bai Xiaolin¹,Wang Xiaohong¹,Wang Yuming¹^ORCID,Li Zhaojie¹,Xue Changhu¹³,Wang Jingfeng¹

Affiliation:

1. College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, Shangdong, China

2. Marine Biomedical Research Institute of Qingdao, Qingdao, 266071, Shandong, China

3. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, Shandong Province, P.R. China

Abstract

Sea cucumber saponins Holothurin A and Echinoside A supplement downregulated PI3K/AKT/β-catenin and OPG/RANKL/NF-κB signaling to alleviate high bone turnover status, and finally improving osteoporosis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO04357A

Reference45 articles.

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