Biochemical, thermodynamic and structural studies of recombinant homotetrameric adenylosuccinate lyase fromLeishmania braziliensis

Author:

Galina Luiza12345,Dalberto Pedro Ferrari12345,Borges Martinelli Leonardo Kras12345,Roth Candida Deves12345,Michel Pinto Antonio Frederico12345,Villela Anne Drumond12345,Bizarro Cristiano Valim12345,Machado Pablo12345,Saraiva Macedo Timmers Luis Fernando67458,Norberto de Souza Osmar12345ORCID,Marcelino de Carvalho Filho Edgar910115,Basso Luiz Augusto12345ORCID,Santos Diogenes Santiago12345

Affiliation:

1. Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF)

2. Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)

3. Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)

4. Porto Alegre

5. Brazil

6. Programa de Pós-Graduação em Biologia Celular e Molecular

7. PUCRS

8. Laboratório de Bioinformática

9. Hospital Universitário Professor Edgard Santos

10. Universidade Federal da Bahia

11. Salvador 40110160

Abstract

Functional and structural data suggested that His197and Ser322residues play a role inLbASL catalysis.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

CNPq

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference56 articles.

1. Leishmaniasis: complexity at the host–pathogen interface

2. WHO , Control of the leishmaniases: report of a meeting of the WHO Expert Committee on the control of Leishmaniases , World Health Organization , Geneva , 2010

3. Leishmaniasis Worldwide and Global Estimates of Its Incidence

4. D. E.Teixeira , et al. , Atlas didático Ciclo de vida da Leishmania , Fundação CECIERJ, Consórcio CEDERJ , Rio de Janeiro , 2013

5. Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects

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