Iodomethane in C1 chemistry: application in palladium-catalyzed [2 + 2 + 1] annulation

Author:

Zhang Jin-Ke1,Fang Yu-Chen12,Chen Jia-He1,Shan Jing1,Bai Mei13,Huang Qiang13ORCID,Chen Yong-Zheng13ORCID,Han Wen-Yong13ORCID

Affiliation:

1. Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi 563006, P. R. China

2. School of Chemistry & Chemical Engineering, Xinjiang Normal University, Urumqi 830054, P. R. China

3. Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, P. R. China

Abstract

A variety of chromone-containing polycyclic compounds were smoothly forged in up to 93% yield via palladium-catalyzed [2 + 2 + 1] annulation of 3-iodochromones, bridged olefins, and iodomethane, in which iodomethane was used as the methylene source.

Funder

Guizhou Science and Technology Department

National Natural Science Foundation of China

Natural Science Foundation of Guizhou Province

Publisher

Royal Society of Chemistry (RSC)

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