Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles-Reference-Cited by-同舟云学术

Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

Published:2015 Issue:10 Volume:13 Page:2879-2883
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Panesar Harmanpreet Kaur¹²³⁴,Solano Jennifer¹²³⁴,Minehan Thomas G.¹²³⁴

Affiliation:

1. Department of Chemistry and Biochemistry

2. California State University

3. Northridge

4. USA

Abstract

N-Monosubstituted andN,N′-disubstituted indolo[3,2-b]carbazole derivatives bind DNA with micromolar to submicromolar affinities and a preference for intercalation at purine-pyrimidine steps.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02566K

Reference35 articles.

1. Indolo[3,2-b]carbazol: Reaktionsprodukt der Umsetzung von 3,3′- Bisindolylmethan mit Orthoameisensäuretriethylester

2. Synthesis and alkylation of indolo[3,2-b]carbazoles

3. Substituent effect on the preferred DNA binding mode and affinity of a homologous series of naphthalene diimides

4. Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

5. NMR Structural Analysis of a Modular Threading Tetraintercalator Bound to DNA

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