Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides

Author:

Botha Filip12345,Slavíčková Michaela12345,Pohl Radek12345,Hocek Michal12345ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry

2. Academy of Science Czech Republic

3. Gilead Sciences and IOCB Research Center

4. 16610 Prague 6

5. Czech Republic

Abstract

Nucleosides or nucleotides were modified by Cu-mediated arylsulfanylations or -selanylations and used in the enzymatic synthesis of DNA bearing arylsulfanyl or arylselanyl groups.

Funder

Czech Science Foundation

Akademie ved Ceské Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference44 articles.

1. Modified Nucleic Acids, Nucleic Acids and Molecular Biology Series, ed. K. Nakatani and Y. Tor, Springer, 2016, vol. 31, pp. 1–276

2. Structural Insights into the Processing of Nucleobase-Modified Nucleotides by DNA Polymerases

3. Nucleoside Triphosphates — Building Blocks for the Modification of Nucleic Acids

4. Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology

5. J. Dadová , H.Cahová and M.Hocek, Polymerase Synthesis of Base-Modified DNA, in Modified Nucleic Acids, ed. K. Nakatani and Y. Tor, Springer International Publishing, Cham, 2016, pp. 123–144

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