DePEGylation strategies to increase cancer nanomedicine efficacy
Author:
Affiliation:
1. Leiden Institute of Chemistry – Supramolecular and Biomaterial Chemistry
2. Leiden University
3. 2333CC Leiden
4. The Netherlands
Abstract
PEGylation of nanoparticles prolongs circulation lifetimes and maximizes nanoparticle accumulation in target tumors. However, PEGylation comes at the cost of reduced cellular uptake of nanoparticles and concomitant drug delivery. This review discusses the various stimuli-responsive dePEGylation strategies that have been employed to overcome this “PEG dilemma”.
Funder
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NH/C8NH00417J
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