Determination of acidity constants at 37 °C through the internal standard capillary electrophoresis (IS-CE) method: internal standards and application to polyprotic drugs-Reference-Cited by-同舟云学术

Determination of acidity constants at 37 °C through the internal standard capillary electrophoresis (IS-CE) method: internal standards and application to polyprotic drugs

Published:2020 Issue:17 Volume:145 Page:5897-5904
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Lebanov Leo¹²³⁴,Fuguet Elisabet¹²³⁴⁵^ORCID,Melo Javier M.¹²³⁴,Rosés Martí¹²³⁴^ORCID

Affiliation:

1. Departament d'Enginyeria Química i Química Analítica and Institut de Biomedicina (IBUB)

2. Universitat de Barcelona

3. Barcelona

4. Spain

5. Serra Húnter Programme

Abstract

This work provides the pK_a at the biorelevant temperature of 37 °C for a set of compounds proposed as internal standards for the internal standard capillary electrophoresis method. The method is applied to pK_a determination of polyprotic drugs.

Funder

Ministerio de Economía y Competitividad

Generalitat de Catalunya

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AN/D0AN00918K

Reference36 articles.

1. Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution

2. The significance of acid/base properties in drug discovery